The effect of mindfulness on decision-making, inhibitory control, and impulsivity of substance use disorder in-treatment patients: A randomized clinical trial.

This study aimed to investigate the effects of Mindfulness-Based Relapse Prevention (MBRP) in decision-making, inhibitory control and impulsivity compared to Treatment as Usual (TAU) for individuals with Substance Use Disorders (SUD's) in Brazil. A randomized clinical trial was conducted with participants from a therapeutic community (n = 122). Decision-making (Iowa Gambling Task), impulsivity dimensions (UPPS-P Scale), and inhibitory control (Stroop Color-Word Test) were assessed before and after the MBRP 8-week intervention. GLM Multivariate analysis was used to evaluate the effects of MBRP on different impulsivity measures. The results showed that MBRP+TAU improved the general decision-making score (p = 0,008) compared to TAU. However, no significant effects were found in impulsivity dimensions and inhibitory control in individuals with SUDs in the therapeutic community. This study found improvement in decision-making in the total IGT score; however, no effect for self-reported impulsivity and inhibitory control among middle-aged patients after an 8-weeks intervention of MBRP protocol in an inpatient setting. It adds information to the subject, with implications and possible directions to be followed by the next clinical trials with patients with SUDs in treatment. Trial registration: EnsaiosClinicos.gov.br: RBR-6c9njc.

Cognitive strategies in matrix-reasoning tasks: State of the art.

Cognitive strategies in matrix-reasoning tasks have been investigated for the last decade and a half. Several steps were made since the first paper in the field, but the advances have been sparse and with little connection. Here we present a review of the state of the art in this subject. We introduce how this topic was born and how to measure these strategies, covering the diverse methods and measures that are presented in the literature to progress on this subject and the applications that were developed, as well as the knowledge that resulted from these applications. Furthermore, the future directions are discussed with the intention to engage new researchers in this topic, as well as to bring awareness to limitations that were found given the available scientific literature.

Neuropsychological profile of patients with infectious disease: characterization and comparison of patients with HIV, HTLV, and HCV.

Understanding the effect of the HIV, HTLV-1, and HCV viruses on cognitive aspects can help in the better characterization of dementia, as well as the best conducts to be suitable for rehabilitation. Thus, the present study aimed to characterize and compare the neuropsychological profile of 3 groups of patients with infectious diseases: HIV, HTLV, and HCV. The results of neuropsychological assessments and depression assessment of 325 people treated at a referral hospital for infectious diseases were analyzed, being 120 HIV carriers (74 (61.7%) men) with an average age of 47.5 years (SD = 10.3), 65 patients with HTLV-1 (16 (24.6%) men) with a mean age of 49.9 years (SD = 12.9), and 87 HCV patients (47 (54%) men) with a mean age of 55.5 years (SD = 11.2). In addition, 54 people (26 (48.1%) men) with negative serology who made up the control group were evaluated. The results of the statistical evaluation of the sociodemographic factors of the four groups (HIV, HTLV-1, HCV, and control) showed that in addition to age, schooling was a significant factor among them and may have a strong influence on the performance of cognitive tests. The HTLV-1 group had the lowest neurocognitive performance and also the highest rate of depressive symptoms.

Event-related potential and lexical decision task in dyslexic adults: Lexical and lateralization effects.

Developmental dyslexia is a specific learning disorder that presents cognitive and neurobiological impairments related to different patterns of brain activation throughout development, continuing in adulthood. Lexical decision tasks, together with electroencephalography (EEG) measures that have great temporal precision, allow the capture of cognitive processes during the task, and can assist in the understanding of altered brain activation processes in adult dyslexics. High-density EEG allows the use of temporal analyses through event-related potentials (ERPs). The aim of this study was to compare and measure the pattern of ERPs in adults with developmental dyslexia and good readers, and to characterize and compare reading patterns between groups. Twenty university adults diagnosed with developmental dyslexia and 23 healthy adult readers paired with dyslexics participated in the study. The groups were assessed in tests of intelligence, phonological awareness, reading, and writing, as well as through the lexical decision test (LDT). During LDT, ERPs were recorded using a 128-channel EEG device. The ERPs P100 occipital, N170 occipito-temporal, N400 centro-parietal, and LPC centro-parietal were analyzed. The results showed a different cognitive profile between the groups in the reading, phonological awareness, and writing tests but not in the intelligence test. In addition, the brain activation pattern of the ERPs was different between the groups in terms of hemispheric lateralization, with higher amplitude of N170 in the dyslexia group in the right hemisphere and opposite pattern in the control group and specificities in relation to the items of the LDT, as the N400 were more negative in the Dyslexia group for words, while in the control group, this ERP was more pronounced in the pseudowords. These results are important for understanding different brain patterns in developmental dyslexia and can better guide future interventions according to the changes found in the profile.

Resilience Programs for Children and Adolescents: A Systematic Review and Meta-Analysis.

Resilience may be defined as the ability to recover and adapt to adverse situations. Given that resilience involves cognitive and behavioral aspects, it could be promoted based on strategies that favor them, especially during childhood and adolescence. As a result, several resilience-focused programs have been developed and studied. This systematic review of Randomized Controlled Trials (RCTs) aimed to assess resilience-focused programs for children (<12 years old) and adolescents (12-22 years old) compared to active (treatment as usual, other program modalities, and educational curriculum at school) or inactive (waiting list, no treatment) control groups. We performed a systematic review of meta-analyses of RCTs. The following databases were searched: Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, and PsycINFO. Two authors independently selected the studies, extracted the data, and assessed the studies' risk of bias. Meta-analyses of random effects were conducted to calculate the standard mean differences (SMD) and 95% confidence interval (CI) of program effectiveness. Of the 17 RCTs that met the inclusion criteria, 13 provided sufficient data to assess the effectiveness of the programs after their implementation. Meta-analyses indicated overall effectiveness of the programs in promoting resilience (SMD = 0.48, 95% CI [0.15, 0.81], p = 0.0077). The subgroup analysis indicated effectiveness only among adolescents' resilience (SMD = 0.48, 95% CI [0.08, 0.88], p = 0.02). The follow-up analysis also indicated evidence of continuation of results within a period of up to 6 months up (SMD = 0.12, 95% CI [-0.44, 0.69], p = 0.02). These results indicated the effectiveness of promoting resilience, especially in adolescents, and its continuation in follow-up analyses. These findings are promising in the field of resilience programs; however, further studies are necessary to analyze the different possible characteristics of programs and their results. Clinical Trial Registration: [https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020179874], [CRD42020179874].

Phonological awareness, rapid automatized naming, and reading of functionally illiterate adults. / Consciência fonológica, nomeação automática rápida e leitura em adultos analfabetos funcionais.

PURPOSE: The study's purpose is to describe the cognitive profile of a sample of functionally illiterate individuals in reading, phonological awareness (PA) and rapid automatized naming (RAN), as well as to correlate the performance of these tasks. Moreover, it sought to understand how the performances in PA and RAN predict results in reading of words and pseudowords. METHODS: 23 functionally illiterate adults were assessed for intelligence, reading, PA and RAN tasks. RESULTS: Participants showed difficulties in PA, performing poorly in tasks involving phoneme analysis and manipulation. In RAN, they found it easier to name alphanumeric items. Regarding reading, they presented difficulties in phonological processing, with errors caused by phonological exchange. Correlation analyses indicated that reading presented higher correlations with RAN than PA. Finally, a regression analysis indicated that performance in RAN can account for more than half of participants' reading results. CONCLUSION: In general, the profile of functionally illiterate adults presents impairment in the abilities assessed that are more evident in PA at phoneme levels as well as in naming of non-alphanumerical items. Moreover, the results in RAN explain those in word and pseudowords reading better than the results in PA.

OBJETIVO: O presente estudo tem como objetivo descrever o perfil de adultos analfabetos funcionais em tarefas de leitura, consciência fonológica (CF), e nomeação automática rápida (NAR); bem como correlacionar o desempenho dessas tarefas. Além disso, buscou-se compreender quanto que o desempenho em CF e NAR predizem o resultado em leitura de palavras e pseudopalavras. MÉTODO: Foram avaliados 23 adultos analfabetos funcionais em tarefas de inteligência, leitura, CF e NAR. RESULTADOS: Os participantes apresentaram dificuldades em CF, tendo pobre desempenho em tarefas que envolviam análise e manipulação de fonemas. Em NAR, apresentaram maior facilidade na nomeação de itens alfanuméricos. Em relação à leitura, houve dificuldades no processamento fonológico, apresentando erros por troca fonológica. Análises de correlação indicaram que a leitura apresentou maiores correlações com NAR do que com CF. Por fim, a análise de regressão indicou que o desempenho em NAR é capaz de explicar mais da metade do resultado em leitura dos participantes. CONCLUSÃO: De modo geral, o perfil dos adultos analfabetos funcionais se caracteriza por apresentar prejuízos nas habilidades avaliadas, sendo esses prejuízos mais evidentes em CF ao nível dos fonemas, bem como na nomeação de itens não-alfanuméricos. Além disso, os resultados em NAR explicam melhor os resultados de leitura de palavras e pseudopalavras do que os resultados em CF.

Cognitive assessment in patients with Hepatitis C submitted to treatment with Sofosbuvir and Simeprevir or Daclatasvir.

BACKGROUND: Hepatitis C can be defined as an infectious disease that develops an inflammatory activity, which may cause an impairment in the central nervous system, may cause cognitive impairments and symptoms of depression. OBJECTIVE: The objective of this study was to verify the cognitive performance of patients with chronic hepatitis C before and after treatment with simeprevir, sofosbuvir, and daclatasvir. METHODS: A prospective study was carried out in three stages: before, right after treatment, and six months after. Fifty-eight patients under clinical follow-up were evaluated at the Emílio Ribas Infectology Institute, in São Paulo, Brazil. The following instruments were used: sociodemographic questionnaire, Lawton's Scale, Beck's Depression Inventory, and a battery of neuropsychological tests that evaluated: intellectual function, memory, attention, executive function, and motor and processing speed). For statistical analysis, the analyses described (mean, frequency, and standard deviation), chi-square, and ANOVA were used. RESULTS: Most of the participants were male (n=30, 51.7%), with a mean of 58.23±8.79 years, mean schooling of 9.75±4.43 years. Comparing the results of neuropsychological evaluations (before, just after completion of drugs, and six months), a significant improvement was observed in relation to the acquisition of new knowledge (p=0.03), late visual memory (p=0.01), and tendency towards alternate attention (p=0.07). CONCLUSION: The treatment of the hepatitis C virus improved cognitive performance, especially in relation to memory.

Rapid Automatized Naming and Explicit Phonological Processing in Children With Developmental Dyslexia: A Study With Portuguese-Speaking Children in Brazil.

Many studies have shown that children with reading difficulties present deficits in rapid automatized naming (RAN) and phonological awareness skills. The aim of this study was to examine RAN and explicit phonological processing in Brazilian Portuguese-speaking children with developmental dyslexia and to explore the ability of RAN to discriminate between children with and without dyslexia. Participants were 30 children with a clinical diagnosis of dyslexia established by the Brazilian Dyslexia Association and 30 children with typical development. Children were aged between 7 and 12, and groups were matched for chronological age and sex. They completed a battery of tests that are commonly used in Brazil for diagnosing dyslexia, consisting of the Wechsler Intelligence Test for Children (WISC-IV) as well as tests of single word and non-word reading, RAN, and the profile of phonological abilities test. Results indicate that the cognitive profile of this group of children, with a clinical diagnosis of dyslexia, showed preserved skills in the four subscales of the WISC-IV (verbal comprehension, perceptual reasoning, working memory, and processing speed) and on the profile of phonological abilities test. Groups significantly differed on the reading tests (word and non-word) and RAN measures, with medium to large effect sizes for RAN. Classification and regression tree analysis revealed that RAN was a good predictor for dyslexia diagnosis, with an overall classification accuracy rate of 88.33%.

Cognitive assessment in patients with Hepatitis C submitted to treatment with Sofosbuvir and Simeprevir or Daclatasvir

BACKGROUND: Hepatitis C can be defined as an infectious disease that develops an inflammatory activity, which may cause an impairment in the central nervous system, may cause cognitive impairments and symptoms of depression. OBJECTIVE: The objective of this study was to verify the cognitive performance of patients with chronic hepatitis C before and after treatment with simeprevir, sofosbuvir, and daclatasvir. METHODS: A prospective study was carried out in three stages: before, right after treatment, and six months after. Fifty-eight patients under clinical follow-up were evaluated at the Emílio Ribas Infectology Institute, in São Paulo, Brazil. The following instruments were used: sociodemographic questionnaire, Lawton's Scale, Beck's Depression Inventory, and a battery of neuropsychological tests that evaluated: intellectual function, memory, attention, executive function, and motor and processing speed). For statistical analysis, the analyses described (mean, frequency, and standard deviation), chi-square, and ANOVA were used. RESULTS: Most of the participants were male (n=30, 51.7%), with a mean of 58.23±8.79 years, mean schooling of 9.75±4.43 years. Comparing the results of neuropsychological evaluations (before, just after completion of drugs, and six months), a significant improvement was observed in relation to the acquisition of new knowledge (p=0.03), late visual memory (p=0.01), and tendency towards alternate attention (p=0.07). CONCLUSION: The treatment of the hepatitis C virus improved cognitive performance, especially in relation to memory

INTRODUÇÃO: A hepatite C pode ser definida como uma doença infecciosa, que se desenvolve por uma atividade inflamatória, que pode gerar um comprometimento no Sistema Nervoso Central, podendo ocasionar prejuízos cognitivos e sintomas de depressão. OBJETIVO: O objetivo deste estudo foi verificar o desempenho cognitivo de pacientes com hepatite C crônica antes e após o tratamento com simeprevir, sofosbuvir e daclatasvir. MÉTODOS: Foi realizado um estudo prospectivo em três etapas: antes, logo após o tratamento e seis meses depois. Foram avaliados 58 pacientes em acompanhamento clínico no Instituto de Infectologia Emílio Ribas, em São Paulo, Brasil. Foram utilizados os seguintes instrumentos: questionário sociodemográfico, Escala de Lawton, Inventário de Depressão de Beck e uma bateria de testes neuropsicológicos que avaliaram: função intelectual, memória, atenção, função executiva e velocidade motora e de processamento). Para análise estatística, foram utilizadas as análises descritas (média, frequência e desvio padrão), qui-quadrado e ANOVA. RESULTADOS: A maioria dos participantes era do sexo masculino (n=30, 51,7%), com média de 58,23±8,79 anos, escolaridade média de 9,75±4,43 anos. Comparando os resultados das avaliações neuropsicológicas (antes, logo após a finalização dos medicamentos e seis meses), observou-se melhora significativa em relação à aquisição de novos conhecimentos (p=0,03), memória visual tardia (p=0,01) e tendência em relação a atenção alternada (p=0,07). CONCLUSÃO: O tratamento do vírus da hepatite C melhorou o desempenho cognitivo, principalmente em relação à memória

Predictors of problematic smartphone use among university students.

Predictors of problematic smartphone use have been found mainly in studies on elementary and high school students. Few studies have focused on predictors related to social network and messaging apps or smartphone model. Thus, the objective of our study was to identify predictors of problematic smartphone use related to demographic characteristics, loneliness, social app use, and smartphone model among university students. This cross-sectional study involved 257 Brazilian university students who answered a smartphone addiction scale, a questionnaire about smartphone usage patterns, and the Brazilian version of the UCLA-R loneliness scale. Women, iPhone owners, and users of Instagram and Snapchat had significantly higher smartphone addiction scores. We found correlations between scores for the Brazilian version of smartphone addiction scale and the importance attributed to WhatsApp, Facebook, Instagram, and Snapchat, and the Brazilian version of the UCLA-R loneliness scale. Our hierarchical regression model predicted 32.2% of the scores of the Brazilian version of the smartphone addiction scale, with the greatest increase in predictive capability by the step that added smartphone social app importance, followed by the step that added loneliness. Adding the smartphone model produced the smallest increase in predictive capability. The theoretical and practical implications of these results are discussed.

Autism Spectrum Disorders: Assessment of cognitive abilities using the non-verbal SON-R 6-40 / Transtorno do Espectro Autista: Avaliação de habilidades cognitivas utilizando o teste não-verbal SON-R 6-40

Abstract Cognition in individuals with Autism Spectrum Disorder (ASD) shows large variability. Nonverbal tests can be more suitable for cognitive assessment in this group. We investigated cognitive abilities in ASD using the SON-R 6-40 Nonverbal Intelligence Test. A total of 37 individuals with ASD (AG) aged 6-24 years participated. Cognitive assessment of the AG was done using the SON-R 6-40 and performance compared with the standardized sample which served as the control group (CG). Results showed lower subtest scores in the AG than in the CG. Approximately 84% of the AG had intellectual disability according to IQ scores. Individuals with preserved speech in the AG had higher IQ scores than patients without preserved speech. There was no relationship between intelligence and ASD symptom severity as reported by families.

Resumo A cognição de indivíduos com Transtorno do Espectro Autista (TEA) apresenta grande variabilidade. Testes não-verbais podem ser mais adequados para avaliação cognitiva desta população. Investigou-se as habilidades cognitivas de indivíduos com TEA a partir do desempenho no Teste não verbal de inteligência SON-R 6-40. Participaram 37 indivíduos com TEA (GTEA) entre 6 e 24 anos, cujo desempenho no SON-R 6-40 foi comparado ao da amostra normativa do instrumento (GC). Houve pior desempenho do GTEA em todos os subtestes, com diferença significativa em relação ao GC. Quase 84% do GTEA apresentou QI compatível com deficiência intelectual. Aqueles com fala preservada apresentaram desempenho superior ao grupo não-verbal. Não houve relação entre inteligência e gravidade dos sintomas conforme relato das famílias.

Predictors of problematic smartphone use among university students

Abstract Predictors of problematic smartphone use have been found mainly in studies on elementary and high school students. Few studies have focused on predictors related to social network and messaging apps or smartphone model. Thus, the objective of our study was to identify predictors of problematic smartphone use related to demographic characteristics, loneliness, social app use, and smartphone model among university students. This cross-sectional study involved 257 Brazilian university students who answered a smartphone addiction scale, a questionnaire about smartphone usage patterns, and the Brazilian version of the UCLA-R loneliness scale. Women, iPhone owners, and users of Instagram and Snapchat had significantly higher smartphone addiction scores. We found correlations between scores for the Brazilian version of smartphone addiction scale and the importance attributed to WhatsApp, Facebook, Instagram, and Snapchat, and the Brazilian version of the UCLA-R loneliness scale. Our hierarchical regression model predicted 32.2% of the scores of the Brazilian version of the smartphone addiction scale, with the greatest increase in predictive capability by the step that added smartphone social app importance, followed by the step that added loneliness. Adding the smartphone model produced the smallest increase in predictive capability. The theoretical and practical implications of these results are discussed.

Low weight, socioeconomics and behavioral issues: examining a population in the Northeast of Brazil.

BACKGROUND: Preterm and low weight children at birth are exposed to higher risks and rates of motor, cognitive, behavioral and emotional problems. Being born under low socioeconomic conditions adds even more complexity to these children. This report describes the emotional and behavioral issues of a group of children who were born in low income families and had low weigh at birth in the Northeast region of Brazil. METHOD: A total of 100 children (47 with adequate and 53 with low weigh) were assessed with the Child Behavior Checklist for behavioral and emotional problems, as well as with the Autism Behavior Checklist for autism symptoms. RESULTS: Results show no difference between the two groups (low and adequate weight) in terms of behavior problems or autism characteristics, however, it shows elevated clinical prevalence's of behavioral and emotional problems and more vulnerability for autism symptoms when compared to the general population. Data also showed the more years children spent in pre-school, the less internalizing problems they manifested. CONCLUSION: This study indicates that the impact of low socioeconomics environment is more prominent in the development of behavioral and emotional problems than low weight at birth, in addition it points to the benefits of pre-school years for the emotional and behavioral adjustment of children from low income and with low weight at birth.

lilacs search strategy for systematic reviews of diagnostic test accuracy studies.

BACKGROUND: There are few publications on search strategies to identify diagnostic test accuracy (DTA) studies in lilacs. OBJECTIVE: To translate and customise medline search strategies for use in lilacs and assess their retrieval of studies in Cochrane DTA systematic reviews. METHOD: We developed a six-step process to translate and customise medline search strategies for use in lilacs (iAHx interface). We identified medline search strategies of published Cochrane DTA reviews, translated/customised them for use in lilacs, ran searches in lilacs and compared the retrieval results of our translated search strategy versus the one used in the published reviews. RESULTS: Our lilacs search strategies translated/customised from the medline strategies retrieved studies in 70 Cochrane DTA reviews. Only 29 of these reviews stated that they had searched the lilacs database and 21 published their lilacs search strategies. Few had used the lilacs database search tools, none exploded the subject headings, and 86% used only English terms. CONCLUSION: Translating and tailoring a medline search strategy for the lilacs database resulted in the retrieval of DTA studies that would have been missed otherwise.

Can a lexical decision task predict efficiency in the judgment of ambiguous sentences?

The lexicon plays a fundamental role in reading, but little is known about how it influences reading efficiency. Thus, this study seeks to identify which lexical factors in a lexical decision task are relevant in a semantic decision test. A total of 33 university students were recruited to perform a lexical decision task and a semantic decision task. The results revealed differences between the three types of words in the lexical decision task for all measures, but only in the regressive saccades for the semantic decision task. Ambiguous sentences triggered fewer regressions than sentences related to objects. The only lexical measure found to predict efficiency was average time on regular words, which predicted 24% of the efficiency. We discuss the implications of the use of a lexical decision task and the use of the inverse efficiency score as a semantic measure, and we discuss how the lexicon can predict semantic comprehension.

Implementação do modelo de resposta à intervenção em uma classe de 5º ano do ensino fundamental da rede pública de ensino: relato de experiência / Implementation of Response to Intervention Model in a class of 5th grade of a public elementary school: experience report

O presente estudo teve como objetivo a aplicação do modelo de Resposta à Intervenção (RTI) em uma turma do 5º ano do Ensino Fundamental de uma escola pública. Participaram 22 crianças, com idades entre 10 e 11 anos. Foi realizada a adaptação da Camada 1 do modelo RTI, que visa a uma intervenção de caráter instrucional, preventivo, ofertada pelo professor a todos os alunos, por meio de estratégias com base em evidências científicas. Os participantes foram avaliados em três momentos: início, meio e final do ano escolar. Testes normatizados de leitura, escrita, aritmética, atenção e motivação foram aplicados a fim de avaliar o progresso das crianças. Além dos testes padronizados, avaliações qualitativas e contínuas foram feitas atendendo o critério de monitoramento prescrito no modelo de RTI. De forma geral, a análise dos resultados demonstrou que o desempenho dos alunos em leitura, escrita, atenção e aritmética obteve melhoras estatisticamente significativas, sendo possível também identificar os alunos com desempenho abaixo da média em relação a seus pares. Tal relato corrobora a eficácia da aplicação do modelo RTI também ao final do ciclo do Ensino Fundamental I.

The present study aims to narrate an experience of application of the Response to Intervention model in a 5th grade class of a Public Elementary School. Twenty-two children, aged 10 and 11, took part in this experience. We used an adaptation of tier 1 of the RTI model that aims for an instructional, preventive intervention, offered by the teacher to all students, through scientific based strategies. The study consisted in three moments of administration of standardized tests for reading, writing, numeracy, attention and motivation: at the beginning of the school year and at the end of the first and last semesters. Besides these tests, we made use of other types of continuous and qualitative assessment, meeting the criteria for monitoring prescribed in the RTI model. The analysis of progress in reading, writing, attention and numeracy showed statistically significant improvement. It is also possible to identify students with below-average performance relative to their peers. This report corroborates the effectiveness of the application of the RTI model also at the end of the Elementary School cycle.

Can a lexical decision task predict efficiency in the judgment of ambiguous sentences?

Abstract The lexicon plays a fundamental role in reading, but little is known about how it influences reading efficiency. Thus, this study seeks to identify which lexical factors in a lexical decision task are relevant in a semantic decision test. A total of 33 university students were recruited to perform a lexical decision task and a semantic decision task. The results revealed differences between the three types of words in the lexical decision task for all measures, but only in the regressive saccades for the semantic decision task. Ambiguous sentences triggered fewer regressions than sentences related to objects. The only lexical measure found to predict efficiency was average time on regular words, which predicted 24% of the efficiency. We discuss the implications of the use of a lexical decision task and the use of the inverse efficiency score as a semantic measure, and we discuss how the lexicon can predict semantic comprehension.

Associations between fetal testosterone and pro-social tendencies, anxiety and autistic symptoms in Williams syndrome: a preliminary study.

Objective: Fetal testosterone (fT) has organizational effects on the developing human nervous system and can be reliably estimated by the ratio between the length of the second and fourth digits - 2D:4D. Previous studies reported altered patterns of fT in some developmental disabilities (e.g. ASD) relative to typically developing individuals (TD). Williams syndrome (WS) is a rare genetic disorder characterized by exacerbated empathy and social approach and heightened anxiety. Recent reports also highlight the co-occurrence of significant levels of autistic symptoms. Despite constituting an interesting model to study androgenic contributions to social behavior, no studies have sought to explore fT in WS. The main aims of this preliminary study were two-fold: (a) to compare 2D:4D in WS and TD; (b) to analyze the pattern of associations between 2D:4D and hypersociability, affective and cognitive empathy, anxiety and autistic symptoms in WS. Methods: 2D:4D were measured from digital scans of the ventral surface of the right hand. Hypersociability, empathy, anxiety and autistic symptoms were obtained from parental reports. Results: There were no significant differences in 2D:4D between WS than TD. In WS lower fT (higher 2D:4D) was significantly associated with hypersociability and affective empathy, as well as marginally associated with anxiety/depression scores. In contrast, cognitive empathy was marginally and negatively associated with 2D:4D, while levels of autistic symptoms were unrelated with this measure. Conclusion: Our results suggest that fT may be implicated in the emergence of several cardinal features of WS, namely hypersociability, affective empathy and anxiety, but not in ASD symptoms.

Desempenho em testes psicopedagógicos e neuropsicológicos de crianças e adolescentes com dislexia do desenvolvimento e dificuldade de aprendizagem / Performance in psychopedagogical and neuropsychological tests of children and adolescents with developmental dyslexia and learning difficulties

Os problemas encontrados durante o processo de aprendizagem constituem uma das razões mais frequentes para a procura por atendimentos por psicopedagogos, psicólogos e fonoaudiólogos. Essas dificuldades têm sido analisadas em função de dois subtipos importantes: Dificuldades de Aprendizagem (DA) e Transtornos Específicos de Aprendizagem (TEAd), sendo a Dislexia do Desenvolvimento (DD) o transtorno com maior prevalência. Dessa forma, um dos aspectos importantes da avalição diagnóstica é o estabelecimento de diagnóstico diferencial. O presente estudo teve por objetivo caracterizar perfis de crianças e adolescentes com DD e DA em testes psicopedagógicos e neuropsicológicos, e compará-los com o perfil do grupo controle. Participaram 45 crianças e adolescentes divididas em três grupos: (G1) 21 sujeitos com DD; (G2) 10 sujeitos com histórico de DA, mas sem apresentar os critérios para diagnóstico do transtorno; (G3) 14 bons leitores, utilizados como grupo controle. Avaliaram-se as seguintes habilidades cognitivas: inteligência, atenção, consciência fonológica, fluência verbal, linguagem receptiva-auditiva, leitura e escrita. ANOVAs unifatoriais foram conduzidas e nos casos em que foram encontradas diferenças significativas entre os grupos, testes post hoc Bonferroni foram realizados. Os resultados apontaram que o grupo com DD apresentou maiores dificuldades em testes que avaliam a memória de trabalho e discriminação visual, além de erros específicos na leitura e escrita. Esse perfil cognitivo evidencia dificuldades específicas na leitura e nas habilidades cognitivas relacionadas a esse processo. Além disto, o estudo evidenciou a heterogeneidade do perfil de crianças com dislexia, bem como possíveis comorbidades com outros transtornos.

The problems encountered during the learning process are one of the most frequent reasons for seeking care by psychopedagogues, psychologists and speech therapists. These difficulties have been analyzed according to two important subtypes: Learning Difficulties (LD) and Specific Learning Disabilities (SLD), Developmental Dyslexia (DD) being the most prevalent disability. Thus, one of the important aspects of diagnostic assessment is the establishment of a differential diagnosis. The present study aimed to characterize the cognitive profiles of children and adolescents with DD and LD in psychopedagogical and neuropsychological tests, and to compare them with the control group. Participated a sample of 45 children and adolescents divided into three groups: (G1) 21 subjects with DD; (G2) 10 subjects with a history of LD, but without the diagnostic criteria for the disability; (G3) 14 good readers, used as a control group. The following cognitive abilities were evaluated: intelligence, attention, phonological awareness, verbal fluency, receptive-auditory language, reading and writing. One-way ANOVAs were conducted and in cases where significant differences were found between groups, post hoc Bonferroni tests were performed. The results indicated that the group with DD presented greater difficulties in tests that evaluate working memory and visual discrimination, besides specific errors in reading and writing. This cognitive profile shows specific difficulties in reading and cognitive abilities related to this process. In addition, the study evidenced the heterogeneity of the dyslexic children profile, as well as possible comorbidities with other disabilities.

Intervenção multissensorial e fônica nas dificuldades de leitura e escrita: um estudo de caso / Multisensory and phonic intervention in reading and writing difficulties: A Case Study

O estudo teve como objetivo avaliar o efeito de intervenção multissensorial e fônica no desenvolvimento de habilidade de leitura e escrita. O estudo foi conduzido com uma criança de 10 anos, sexo masculino, estudante do 3º do Ensino Fundamental I, proveniente de uma escola particular da cidade de São Paulo, com queixa de dificuldades em leitura e escrita. Foram realizadas avaliações pré e pós à intervenção com os seguintes instrumentos: Escala de Inteligência Wechsler para Crianças (WISC-III); Prova de Consciência Fonológica por Produção Oral; Bateria de Avaliação de Leitura e Escrita (BALE); Teste de Desempenho Escolar; Leitura de Texto; Teste de Repetição de Palavras e Pseudopalavras; Redação Temática. As atividades foram desenvolvidas a partir de uma revisão da literatura para elaborar uma proposta de intervenção baseada em evidências científicas. Foram realizadas 20 sessões de intervenção focadas em estratégias fônicas e multissensoriais, durante período de três meses. Os resultados obtidos a partir da comparação de desempenho pré e pós indicaram que houve melhoras nas habilidades de consciência fonológica, compreensão verbal, acurácia de leitura e escrita de palavras após o período de intervenção. Espera-se que este trabalho possa contribuir para a atuação psicopedagógica clínica e educacional, uma vez que elaborar programas de intervenções baseados em evidências pode fundamentar uma prática mais consistente que permita avaliar e identificar melhoras nas habilidades após um curto período de tempo.

The aim of the study was to develop a multisensory intervention program used in the psychopedagogical practice for reading and writing skills. The study was conducted with a 10-year-old male, a student in 3rd grade of Elementary School, who came from a private school in the city of São Paulo, complaining of difficulties in reading and writing. Pre- and post-intervention evaluations were performed with the following instruments: Wechsler Intelligence Scale for Children (WISC-III); Phonological Awareness by Oral Production; Reading and Writing Assessment Battery (BALE); School Performance Test; Reading Text; Test of Word and Pseudowords Repetition; Thematic Writing. The activities were developed based on a review of the literature to elaborate a proposal of intervention based on scientific evidences. Twenty intervention sessions focused on phonic and multisensory strategies were performed during a period of three months. The results obtained from the comparison of pre-and post-performance indicated that there were improvements in phonological awareness skills, verbal comprehension, reading accuracy and word writing after the intervention period. It is hoped that this work may contribute to clinical and educational psychopedagogical performance, since the development of evidence-based intervention programs can support a more consistent practice that allows to evaluate and identify improved skills after a short period of time.